Key result
A high-fat diet over 12 weeks in rabbits induced cardiac fibrosis, increased plasma homocysteine (24.3 vs 16.9 micromol/L), and increased TGF-beta1 compared with lean rabbits.
Why the study?
Does a high-fat diet induce cardiac fibrosis and alter extracellular matrix components in a rabbit model?
Does a high-fat diet induce cardiac fibrosis and alter extracellular matrix components in a rabbit model?
Absolute Event Rate: 24.3% vs 16.9%
A 12-week high-fat diet in a rabbit model induces cardiac fibrosis, characterized by collagen accumulation, increased homocysteine and TGF-beta1, and decreased decorin.
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High-fat diet effects on cardiac fibrosis remain unproven in humans; leaves open translation from rabbit models to clinical practice.
Carroll et al. (2005) studied Obesity-induced cardiac fibrosis and hypertrophy. High-fat diet vs. Lean rabbits was evaluated on Plasma homocysteine concentration (micromol/L). A high-fat diet over 12 weeks in rabbits induced cardiac fibrosis, increased plasma homocysteine (24.3 vs 16.9 micromol/L), and increased TGF-beta1 compared with lean rabbits.
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