What question did this study set out to answer?

This research aims to identify genetic factors influencing acute insulin secretion and their relation to diabetes in Pima Indians.

April 1, 1994Diabetes

Linkage Analysis of Acute Insulin Secretion With GLUT2 and Glucokinase in Pima Indians and the Identification of a Missense Mutation in GLUT2

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Randomized trial assesses linkage of GLUT2 and AIR in Pima Indians, suggesting genetic influence on insulin response.

This research aims to identify genetic factors influencing acute insulin secretion and their relation to diabetes in Pima Indians.
Performed sib-pair linkage analyses for GLUT2 and glucokinase genes with AIR measurements.
Screened GLUT2 for mutations using polymerase chain reaction-single-strand conformation polymorphism analysis.
Investigated familial aggregation of AIR in Pima Indians.
Linkage between GLUT2 and acute insulin response was observed (P=0.04).
No significant linkage was found between glucokinase and AIR or NIDDM.
Identified a missense mutation in GLUT2 affecting 5% of the population, but no association with low AIR.

Janssen et al. (1994) studied this question.

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