Key result
Bedtime administration of antihypertensive medications more effectively controls nocturnal blood pressure and improves the diurnal/nocturnal blood pressure ratio compared to morning dosing.
This review emphasizes the importance of chronobiology in hypertension management, noting that nocturnal blood pressure is a strong predictor of cardiovascular risk and supports the use of chronotherapy.
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Hypothesis-generating for chronotherapy in hypertension; prospective outcome trials needed before practice change.
Latha et al. (2011) conducted a review in Hypertension. Chronotherapy (timing of antihypertensive administration) was evaluated. Bedtime administration of antihypertensive medications more effectively controls nocturnal blood pressure and improves the diurnal/nocturnal blood pressure ratio compared to morning dosing.
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