Key result
Calibration of left ventricle mechanical properties using segmental strain metrics reduced the mean difference between experimental and computational circumferential strains from 0.129 to 0.046.
Why the study?
The authors sought to calibrate mechanical properties of the LV based on 3D speckle tracking echocardiographic imaging data from 16 AHA-defined segments.
The calibration of mechanical properties for myocardium can be improved using segmental strain metrics, highlighting the importance of realistic fiber orientation and geometry for modeling of the LV.
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Segmental strain calibration sharpens LV model fidelity; leaves open whether it improves clinical predictions or requires prospective validation.
We sought to calibrate mechanical properties of left ventricle (LV) based on three-dimensional (3D) speckle tracking echocardiographic imaging data recorded from 16 segments defined by American Heart Association (AHA). The in vivo data were used to create finite element (FE) LV and biventricular (BV) models. The orientation of the fibers in the LV model was rule based, but diffusion tensor magnetic resonance imaging (MRI) data were used for the fiber directions in the BV model. A nonlinear fiber-reinforced constitutive equation was used to describe the passive behavior of the myocardium, whereas the active tension was described by a model based on tissue contraction (Tmax). isight was used for optimization, which used abaqus as the forward solver (Simulia, Providence, RI). The calibration of passive properties based on the end diastolic pressure volume relation (EDPVR) curve resulted in relatively good agreement (mean error = -0.04 ml). The difference between the experimental and computational strains decreased after segmental strain metrics, rather than global metrics, were used for calibration: for the LV model, the mean difference reduced from 0.129 to 0.046 (circumferential) and from 0.076 to 0.059 (longitudinal); for the BV model, the mean difference nearly did not change in the circumferential direction (0.061) but reduced in the longitudinal direction from 0.076 to 0.055. The calibration of mechanical properties for myocardium can be improved using segmental strain metrics. The importance of realistic fiber orientation and geometry for modeling of the LV was shown.
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Dabiri et al. (2019) studied Left ventricle mechanical properties modeling. Calibration using segmental strain metrics vs. Calibration using global strain metrics was evaluated on Difference between experimental and computational strains. Calibration of left ventricle mechanical properties using segmental strain metrics reduced the mean difference between experimental and computational circumferential strains from 0.129 to 0.046.
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