Key result
Untreated hypertension increased the risk of out-of-hospital cardiac arrest compared to no hypertension, whereas antihypertensive treatment reduced the risk to baseline levels.
Why the study?
Hypertension is a major cardiovascular risk factor, but its effect on out-of-hospital cardiac arrest incidence and whether this effect differs by antihypertensive medication needed investigation.
Does antihypertensive treatment reduce the incidence of out-of-hospital cardiac arrest in patients with hypertension?
Case-Control (n=7,899)
Yes
Does antihypertensive treatment reduce the incidence of out-of-hospital cardiac arrest in patients with hypertension?
Answers are grounded in this paper and cite their sources.
Untreated hypertension significantly increases the risk of out-of-hospital cardiac arrest, but antihypertensive treatment mitigates this risk to levels comparable to normotensive individuals.
Hypertension (HTN) is a high risk factor for major cardiovascular adverse events. This study aimed to investigate the effect of HTN risk on out-of-hospital cardiac arrest (OHCA) incidence and determine whether the effect of HTN on OHCA incidence differs according to antihypertensive medication.This case-control study used the Korean Cardiac Arrest Resuscitation Consortium and Korean Community Health Survey (CHS). Cases were defined as emergency medical service-treated adult OHCA patients presumed to have a cardiac etiology from 2015 to 2017. Patients without information on HTN diagnosis were excluded from the study. The Korean CHS database's controls were matched at a 1:2 ratio with strata, including age, gender, and county of residence. Multivariable conditional logistic regression analysis was conducted to estimate HTN risk and antihypertensive treatment on OHCA incidence,A total of 2633 OHCA patients and 5266 community-based controls were enrolled in this study. Among them, 1176 (44.7%) patients and 2049 (38.9%) controls were diagnosed with HTN. HTN was associated with an increased risk of OHCA (adjusted odds ratio [AOR]: 1.19 [1.07-1.32]). On comparing HTN with or without the antihypertensive treatment group with the non-HTN-diagnosed group (as a reference), the HTN without treatment group had the highest AOR (95% confidence interval) (3.41 [2.74-4.24]). The AOR in the HTN treatment group was reduced to that in the non-HTN-diagnosed group (0.96 [0.86-1.08]).HTN increased OHCA risk, and the HTN without treatment group had the highest OHCA risk. Conversely, OHCA risk decreased to the non-HTN-diagnosed group level with HTN treatment.
No takes yet. Share an insight, caveat, or question.
Kim et al. (2022) conducted a case-control in Out-of-hospital cardiac arrest (OHCA) (n=7,899). Hypertension without treatment vs. No hypertension diagnosis was evaluated on Out-of-hospital cardiac arrest incidence (AOR 3.41, 95% CI 2.74-4.24). Untreated hypertension increased the risk of out-of-hospital cardiac arrest compared to no hypertension, whereas antihypertensive treatment reduced the risk to baseline levels.
Synapse has enriched 10 related papers. Consider them for comparative context: