Key result
In children with short stature, a higher TyG index was significantly associated with decreased peak growth hormone when the TyG index was greater than 7.8 (β -2.61).
Why the study?
Growth hormone secretion is influenced by factors like weight and puberty, reproducibility of GH provocation tests is poor, and whether the TyG index associates with peak GH in children with short stature is unclear.
Is the triglyceride glucose (TyG) index associated with peak growth hormone levels in children with short stature?
Cross-Sectional (n=1,095)
No
Is the triglyceride glucose (TyG) index associated with peak growth hormone levels in children with short stature?
In children with short stature, a higher triglyceride glucose index (>7.8) is significantly associated with decreased peak growth hormone levels, suggesting a link between insulin resistance and growth hormone secretion.
Growth hormone (GH) secretion is related to many factors, such as weight and puberty, and the reproducibility of GH provocation tests is very poor. This study aimed to evaluate whether the triglyceride (TyG) index was associated with peak GH in children with short stature. This study included 1095 children with short stature divided into two groups based on peak GH level in GH provocation tests [GH deficiency (GHD) group = 733 children; non-GHD group = 362 children]. We found that the TyG index was significantly higher in the GHD group than in the non-GHD group (P < 0.001). A nonlinear relationship was detected between the TyG index and peak GH, whose point was 7.8. A significant negative association between the TyG index and peak GH was observed when the TyG index was greater than 7.8 (β - 2.61, 95% CI - 3.98, - 1.24; P < 0.001), whereas, the relationship between the TyG index and peak GH was not significant when the TyG index was lower than 7.8 (β 0.25, 95% CI - 1.68, 2.17; P = 0.799). There is a nonlinear relationship between the TyG index and peak GH, and a higher TyG index is associated with decreased peak GH in children with short stature.
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Zhao et al. (2021) conducted a cross-sectional in Short stature (n=1,095). Triglyceride glucose (TyG) index was evaluated on Peak growth hormone (GH) level (β -2.61, 95% CI -3.98, -1.24, p=<0.001). In children with short stature, a higher TyG index was significantly associated with decreased peak growth hormone when the TyG index was greater than 7.8 (β -2.61).
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