Key result
In children with short stature, peak growth hormone response was negatively correlated with BMI, and the diagnosis rate of growth hormone deficiency significantly increased from 16.67% to 76.47% with increasing BMI SDS.
Why the study?
Studies evaluating the effects of body mass index and blood lipids on peak growth hormone levels during growth hormone stimulation tests are scarce.
Do body mass index and blood lipid levels affect peak growth hormone response during provocation testing in children with short stature?
Observational (n=128)
No
Do body mass index and blood lipid levels affect peak growth hormone response during provocation testing in children with short stature?
In children with short stature, higher BMI and waist circumference are associated with blunted peak growth hormone responses during provocation testing, which may increase the likelihood of a false-positive growth hormone deficiency diagnosis.
Higher BMI and lipids correlate with lower peak GH and more GHD diagnoses; leaves open whether BMI-adjusted cutoffs improve test accuracy.
Aim: Short stature is a common developmental problem in children. Growth hormone deficiency (GHD) is a common type, and its diagnosis depends on growth hormone stimulation tests. However, there are few studies on the effects of body mass index (BMI) and blood lipid on the peak GH in a growth hormone stimulating test. Methods: In this retrospective study, we enrolled 128 children with short stature between October 2018 and October 2022, analyzed the influence of BMI and blood lipid on the peak results of drug stimulation test in children with short stature. Results: The results showed that peak GH was negatively correlated with BMI and waist circumference. IGF-1 was positively correlated with peak GH. TC, TG, HDLC and LDLC were negatively correlated with peak GH in children with short stature when LH>0.3IU/L, while IGF-BP3 was positively correlated with peak GH in children when LH<0.83IU/L. Multiple stepwise regression analysis showed that waist circumference, BMI, IGF-1, TC and TG were the influencing factors of peak GH. The growth hormone deficiency (GHD) incidence significantly increased with the elevated BMI SDS. Our study indicated that waist circumference, BMI, IGF-1, TC, and TG are the influencing factors of GH peak, and the correlation of various indicators differs with the different pubertal stages in the clonidine-insulin combined provocation test. Conclusion: Thus, the influence of waist circumference, BMI, IGF-1, TC, TG and pubertal status should be fully considered when interpretating the provocative test results.
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Zhang et al. (2023) conducted an observational in Short stature (n=128). Body Mass Index and blood lipids was evaluated on Peak Growth Hormone (GH) response. In children with short stature, peak growth hormone response was negatively correlated with BMI, and the diagnosis rate of growth hormone deficiency significantly increased from 16.67% to 76.47% with increasing BMI SDS.
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