Key result
Peak GH predicts lower body fat and IGF-1 predicts higher free fat mass in short-statured children.
Why the study?
This study was conducted to investigate the relationship between body composition and the growth hormone/insulin-like growth factor-1 axis in children and adolescents with short stature.
Cross-Sectional (n=310)
No
Effect estimate: β = -0.147 (GH peak and PBF); β = 0.258 (IGF-1 SDS and FFMI)
p-value: p=<0.001
In children and adolescents with short stature, serum GH is associated with body fat, whereas IGF-1 SDS is associated with lean body weight.
May associate body composition with GH/IGF-1 axis in short stature; leaves open whether BIA informs clinical decisions.
This study aimed to investigate the relationship between body composition and the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis in children and adolescents with short stature. All participants underwent a bioelectrical impedance analysis (BIA) and growth hormone stimulation tests, and their percentage of body fat (PBF), fat mass index (FMI), free fat mass index (FFMI), and skeletal muscle index (SMI) were calculated. The study included 310 individuals aged 10.19 ± 3.24 years, with height standard deviation score (SDS) of − 2.44 ± 0.56 and the mean peak of GH was 7.20 ± 5.11 ng/mL. Pearson analysis demonstrated that peak GH value negatively correlated with PBF and FMI. Contrastingly, IGF-1 SDS was positively correlated with FFMI and SMI. Multiple linear regression analysis showed that GH peak and IGF-1 SDS were independent predictors of PBF/FMI and FFMI/SMI, respectively. Serum GH and IGF-1 SDS were associated with body fat and lean body weight, respectively.
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Hou et al. (2022) conducted a cross-sectional in Short stature (n=310). Growth hormone (GH) peak and insulin-like growth factor-1 (IGF-1) SDS was evaluated on Body composition parameters (Percentage of body fat [PBF], fat mass index [FMI], free fat mass index [FFMI], and skeletal muscle index [SMI]) (β = -0.147 (GH peak and PBF); β = 0.258 (IGF-1 SDS and FFMI), p=<0.001). Peak growth hormone was an independent negative predictor of body fat percentage (β = -0.147), whereas IGF-1 SDS independently predicted free fat mass index (β = 0.258) in children and adolescents with short stature.
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