Key result
Higher BMI links to elevated SBP only in children with severe growth hormone deficiency.
Why the study?
In children with growth hormone deficiency, attention has focused solely on height, and few studies have assessed its potential impact on blood pressure.
Does severe growth hormone deficiency modify the effect of BMI on systolic blood pressure in children with short stature?
Cross-Sectional (n=736)
No
Does severe growth hormone deficiency modify the effect of BMI on systolic blood pressure in children with short stature?
Effect estimate: β = 3.12 (95% CI 1.40-4.84)
p-value: p=<0.001
In children with short stature, severe growth hormone deficiency is associated with higher systolic blood pressure and amplifies the hypertensive effect of increased BMI.
May warrant closer BP monitoring in short-stature children with severe GHD; leaves open whether deficiency modifies BMI-BP risk independently of adiposity.
Blood pressure (BP), especially systolic BP (SBP), is higher in adult growth hormone deficiency (AGHD) patients than in normal controls. Additionally, obesity is a known risk factor for hypertension, and growth hormone deficiency (GHD) is an important cause of short stature. For children with GHD, attention has been directed solely towards height. Few studies have assessed its potential impact on BP. Here, we investigated the effect of body mass index standard deviation score (BMISDS) on BP in children with short stature. This study included 736 children with short stature divided into two groups based on peak growth hormone (GH) level in GH provocation tests [severe GHD (SGHD) group = 212 children; non-SGHD group = 524 children]. We found that SBP was significantly higher in the SGHD group than in the non-SGHD group (p = 0.045). Additionally, there was a significant positive association between BMISDS and SBP in the SGHD group (β = 3.12, 95% CI: 1.40-4.84, p < 0.001), but no association between these variables was observed in the non-SGHD group. Thus, SGHD patients had a higher SBP than non-SGHD patients. BMISDS is a significant factor for higher SBP in SGHD patients but not in non-SGHD patients.
No takes yet. Share an insight, caveat, or question.
Li et al. (2019) conducted a cross-sectional in Short stature (n=736). Body mass index standard deviation score (BMISDS) was evaluated on Association between BMISDS and systolic blood pressure in children with severe growth hormone deficiency (SGHD) (β = 3.12, 95% CI 1.40-4.84, p=<0.001). In children with severe growth hormone deficiency, body mass index standard deviation score was independently and positively associated with systolic blood pressure (β = 3.12), an association not observed in those without severe deficiency.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: