May 1, 2002The Journal of Clinical Endocrinology & Metabolism

Familial Isolated Growth Hormone Deficiency Is Associated with Increased Systolic Blood Pressure, Central Obesity, and Dyslipidemia

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Population

16 GH-naive, GH-deficient (GHD) adults with a homozygous defect in the GHRH receptor gene

Design

Case-control

Authors

JBJosé Augusto Soares Barreto-FilhoUniversidade Federal de Sergipe MAMarta Regina Silva AlcântaraUniversidade Federal de Sergipe RSRoberto SalvatoriJohns Hopkins University

Discussion

Member takes

Implication

Metabolic risks in GHD may warrant monitoring; leaves open whether reduced LV mass is adaptive or requires prospective study.

Structured PICO

Population

16 GH-naive, GH-deficient (GHD) adults with a homozygous defect in the GHRH receptor gene

Comparator

31 age-, sex-, and body mass index-matched control (CO) subjects

Outcome

Anthropometric, metabolic, and cardiovascular measurements (at rest, during treadmill exercise, and during orthostatic stress) and echocardiographic datasurrogate

Familial isolated growth hormone deficiency is associated with central obesity, dyslipidemia, and elevated systolic blood pressure, but paradoxically reduced cardiac dimensions and lower insulin resistance.

Cite This Study

Barreto-Filho et al. (2002) studied this question.

synapsesocial.com/papers/6a8530984b2893ddcbc6b247 https://doi.org/10.1210/jcem.87.5.8474

Topics

Echocardiography

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Familial Isolated Growth Hormone Deficiency Is Associated with Increased Systolic Blood Pressure, Central Obesity, and Dyslipidemia

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Familial Isolated Growth Hormone Deficiency Is Associated with Increased Systolic Blood Pressure, Central Obesity, and Dyslipidemia

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider