Why the study?
Does diuretic-free antihypertensive therapy with verapamil and/or enalapril reduce blood pressure without adverse metabolic effects in hypertensive patients with NIDDM?
Population
47 hypertensive patients with non-insulin-dependent diabetes mellitus (NIDDM)
Comparison
Verapamil or enalapril alone, and if blood… vs Baseline
Design
RCT, Randomly received verapamil or enalapril alone
Follow-up
30 weeks
Authors
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Supports diuretic-free verapamil or enalapril regimens in hypertensive type 2 diabetes; confirms metabolic neutrality in this RCT.
Does diuretic-free antihypertensive therapy with verapamil and/or enalapril reduce blood pressure without adverse metabolic effects in hypertensive patients with NIDDM?
Diuretic-free therapy with verapamil and/or enalapril effectively reduces blood pressure in hypertensive patients with NIDDM without adversely affecting carbohydrate and lipid metabolism.
Ferrier et al. (1991) studied this question.
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