Why the study?
Does combined verapamil-trandolapril improve metabolic and renal profiles compared to atenolol-chlortalidone in hypertensive type 2 diabetics?
Population
24 non-insulin-dependent diabetic hypertensives with diastolic blood pressure 90-115 mmHg without azotemia
Comparison
Combined slow-release verapamil and trandolapril… vs Combined atenolol and chlortalidone for 12 weeks
Design
RCT, randomized, double-blind
Follow-up
12 weeks
Authors
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Supports verapamil-trandolapril over atenolol-chlortalidone in diabetic hypertension for metabolic and renal benefits; extends therapy selection beyond BP control alone.
Does combined verapamil-trandolapril improve metabolic and renal profiles compared to atenolol-chlortalidone in hypertensive type 2 diabetics?
In hypertensive patients with type 2 diabetes, a verapamil-trandolapril combination provides similar blood pressure reduction to atenolol-chlortalidone but with a favorable metabolic and antiproteinuric profile.
Schneider et al. (1996) studied this question.
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