Why the study?
Does verapamil SR plus trandolapril improve glycemic control compared to atenolol plus chlorthalidone in hypertensive patients with type 2 diabetes?
Population
463 hypertensive outpatients with non-insulin treated type 2 diabetes on stable antidiabetic therapy for at…
Comparison
Fixed combination of verapamil sustained release… vs Fixed combination of atenolol plus…
Design
RCT, randomized, double blind
Follow-up
20 weeks
Authors
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Supports verapamil SR plus trandolapril over atenolol plus chlorthalidone to stabilize glycemia in diabetic hypertension; extends RCT evidence on regimen-specific metabolic effects.
Does verapamil SR plus trandolapril improve glycemic control compared to atenolol plus chlorthalidone in hypertensive patients with type 2 diabetes?
In patients with type 2 diabetes and hypertension, antihypertensive therapy with verapamil SR plus trandolapril provides better glycemic control than atenolol plus chlorthalidone while achieving comparable blood pressure reductions.
H. Holzgreve (2003) studied this question.
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