Key result
Late gadolinium enhancement extent, location, and pattern were stronger independent predictors of ventricular tachycardia and major adverse cardiac events in patients with non-ischemic cardiomyopathy compared to ischemic cardiomyopathy.
Why the study?
Differences in the association between CMR LGE characteristics and prognosis in patients with ischemic versus non-ischemic cardiomyopathy remain incompletely understood.
Population
168 consecutive patients with ICM or NICM undergoing CMR
Comparison
LGE extent, location, and pattern characteristics in ICM vs NICM
Design
Cohort study
Authors
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Supports LGE integration into NICM risk stratification; hypothesis-generating and requires prospective validation before practice change.
Cohort (n=168)
No
Effect estimate: HR 14.14 (95% CI 4.03-19.61)
p-value: p=0.048
Late gadolinium enhancement extent, location, and pattern on CMR are powerful independent predictors of ventricular tachycardia and major adverse cardiac events, with a stronger prognostic impact in patients with non-ischemic compared to ischemic cardiomyopathy.
Tat et al. (2022) conducted a cohort in Ischemic and non-ischemic cardiomyopathy (n=168). Late gadolinium enhancement (LGE) characteristics vs. Absence of specific LGE characteristics / ICM vs NICM was evaluated on Ventricular tachycardia (sustained or non-sustained) (HR 14.14, 95% CI 4.03-19.61, p=0.048). Late gadolinium enhancement extent, location, and pattern were stronger independent predictors of ventricular tachycardia and major adverse cardiac events in patients with non-ischemic cardiomyopathy compared to ischemic cardiomyopathy.
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