What question did this study set out to answer?

This research aims to analyze the surface markers and functional capacities of leukaemic cells in patients with hairy cell leukaemia.

Hairy Cell Leukaemia: Surface Markers and Functional Capacities of the Leukaemic Cells Analysed in Eight Patients

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Analysis of surface markers and functions in hairy cell leukaemia, indicating B-cell lineage significance.

This research aims to analyze the surface markers and functional capacities of leukaemic cells in patients with hairy cell leukaemia.
Peripheral blood and spleen cells from eight patients with hairy cell leukaemia were analyzed.
Only tartrate resistant isoenzyme 5 containing cells were considered.
Functional assays included adherence, ingestion of latex particles, and analysis of immunoglobulin expression.
Hairy cells adhered to glass and plastic, ingested latex particles, but did not phagocytose sensitized erythrocytes.
Fc-receptors with high binding affinity for aggregated IgG were present on hairy cells.
Varied immunoglobulin chain expressions were observed, confirming the B-cell lineage of hairy cells.

Rieber et al. (1979) studied this question.

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