Key result
Prolonged sitting for 3 hours significantly increased pulse wave velocity (MD 0.30 m/s, p<0.01) and decreased augmentation index, with no systemic changes in circulating angiogenic cells.
Why the study?
The study was conducted to assess the effects of prolonged sitting on measures of arterial stiffness and circulating angiogenic cells in healthy but sedentary adults.
Do intermittent calf raises prevent increases in arterial stiffness and decreases in circulating angiogenic cells during 3 hours of prolonged sitting in healthy sedentary adults?
RCT
Crossover
Do intermittent calf raises prevent increases in arterial stiffness and decreases in circulating angiogenic cells during 3 hours of prolonged sitting in healthy sedentary adults?
Effect estimate: MD 0.30 m/s
p-value: p=<0.01
Prolonged sitting acutely increases aortic arterial stiffness, but intermittent calf raises and sitting do not appear to systemically alter circulating angiogenic cell counts or gene expression.
Prolonged sitting acutely increases aortic stiffness without altering angiogenic cells; confirms vascular effects of sedentariness while leaving open short-bout movement efficacy.
To assess the effects of prolonged sitting on measures of arterial stiffness (AS) and circulating angiogenic cells (CAC), healthy but sedentary subjects completed 3 hours of sitting in a randomized crossover design with 10 calf raises every ten minutes (CALF) or a control condition (CON). Pulse wave velocity (PWV) and pulse wave analysis (PWA) and blood draws were performed pre and post to assess AS. CACs were isolated from venous blood for analysis. PWV significantly increased (Mean Difference [MD]0.30 m/s (0.46), p<0.01) and augmentation index (AIx) from PWA significantly decreased from pre-to post (MD=-9.14% (11.09), p<0.001). There was no significant change in CAC counts per 500,000 events or gene expression in either condition across time. In conclusion, aortic AS increases during sitting despite decreases in arterial wave reflection, and local changes observed previously with physical activity do not persist systemically.
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William Evans (2019) conducted an RCT in Healthy sedentary adults. Sitting with calf raises vs. Control condition (prolonged sitting without calf raises) was evaluated on Arterial stiffness (Pulse wave velocity and augmentation index) and circulating angiogenic cells (MD 0.30 m/s, p=<0.01). Prolonged sitting for 3 hours significantly increased pulse wave velocity (MD 0.30 m/s, p<0.01) and decreased augmentation index, with no systemic changes in circulating angiogenic cells.
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