Key result
Estimated PWV fails to capture the increase in arterial stiffness during prolonged sitting.
Why the study?
Arterial stiffness measured by PWV may link sedentary behavior to CVD, but whether mathematically estimated cfPWV tracks acute vascular responses to prolonged sitting compared with measured cfPWV and crPWV was unclear.
Does mathematically estimated pulse wave velocity (ePWV) accurately track acute arterial stiffness responses to prolonged sitting compared to measured cfPWV and crPWV in overweight/obese adults with elevated blood pressure?
Population
25 overweight/obese adults with elevated blood pressure
Comparison
Measured cfPWV and crPWV vs mathematically estimated cfPWV during prolonged sitting
Design
Secondary analysis
Follow-up
8 h
Authors
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ePWV may miss acute stiffness rises during sitting; leaves open its validity for dynamic vascular assessments in observational data.
Observational (n=25)
Does mathematically estimated pulse wave velocity (ePWV) accurately track acute arterial stiffness responses to prolonged sitting compared to measured cfPWV and crPWV in overweight/obese adults with elevated blood pressure?
Effect estimate: β 0.52
p-value: p=<0.05
Mathematically estimated pulse wave velocity (ePWV) correlates with measured PWV at baseline but fails to capture acute increases in arterial stiffness induced by prolonged sitting.
Alansare et al. (2022) conducted an observational in Overweight/obese with elevated blood pressure (n=25). Prolonged sitting vs. Baseline was evaluated on Change in carotid-femoral pulse wave velocity (cfPWV) over time (β 0.52, p=<0.05). Estimated pulse wave velocity correlated with measured carotid-femoral PWV at baseline (r=0.69) but did not capture the significant increase in arterial stiffness during 8 hours of prolonged sitting.
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