Key result
Periostin expression promotes metastatic potential and aggressiveness of colorectal cancer via the PI3K/Akt signaling pathway, serving as a potential prognostic marker.
Why the study?
To summarize information regarding periostin and emphasize its role as a prognostic marker in colorectal cancer.
Does periostin expression serve as a prognostic marker in colorectal cancer?
Does periostin expression serve as a prognostic marker in colorectal cancer?
Periostin expression may serve as a prognostic marker for colorectal cancer aggressiveness and metastatic potential.
Periostin may aid colorectal cancer prognostication; leaves open prospective validation before clinical adoption.
Accumulating evidence suggests that periostin is frequently upregulated in tissue injury, inflammation, fibrosis and tumor progression. Periostin expression in cancer cells can promote metastatic potential of colorectal cancer (CRC) via activating PI3K/Akt signaling pathway. Moreover, periostin is observed mainly in tumor stroma and cytoplasm of cancer cells, which may facilitate aggressiveness of CRC. In this review, we summarize information regarding periostin to emphasize its role as a prognostic marker of CRC.
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Deng et al. (2019) conducted a review in Colorectal cancer. Periostin was evaluated. Periostin expression promotes metastatic potential and aggressiveness of colorectal cancer via the PI3K/Akt signaling pathway, serving as a potential prognostic marker.
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