March 21, 2007Echocardiography
Utility of the Myocardial Performance Index in a Population with High Prevalences of Obesity, Diabetes, and Hypertension: The Strong Heart Study
Key result
The myocardial performance index did not predict fatal and nonfatal cardiovascular events (RR 1.06; 95% CI 0.56-2.04; P=0.85) in a high-risk population without overt cardiovascular disease.
Why the study?
Does the myocardial performance index (MPI) predict incident cardiovascular events in American Indian adults without overt cardiovascular disease?
Population
1,862 American Indian participants free of coronary or valvular disease or LV systolic dysfunction, mean age…
Design
Cohort
Follow-up
mean 7.1 +/- 2.2 years
Authors
Discussion
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Implication
MPI lacks predictive utility here and should not guide risk assessment; leaves open its value in other populations or with refined metrics.
Study Design
Type
Cohort (n=1,862)
Structured PICO
Does the myocardial performance index (MPI) predict incident cardiovascular events in American Indian adults without overt cardiovascular disease?
P
Population
1,862 American Indian participants free of coronary or valvular disease or LV systolic dysfunction, mean age 59 +/- 8 years, 66% women, with high prevalence of diabetes (48%), hypertension (44%), and obesity (54%).
I
Intervention
Myocardial performance index (MPI) assessed from echocardiographic Doppler recordings
O
Outcome
Incident CV events, including nonfatal stroke, coronary heart disease, congestive heart failure, and CV deathcomposite
Main Result
Effect estimate: RR 1.06 (95% CI 0.56-2.04)
p-value: p=0.85
In a high-risk population without overt cardiovascular disease, the myocardial performance index (MPI) has limited utility and does not predict incident cardiovascular events.
Cite This Study
Mishra et al. (2007) conducted a cohort in High prevalence of obesity, diabetes, and hypertension without overt cardiovascular disease (n=1,862). Myocardial performance index (MPI) was evaluated on Incident cardiovascular events, including nonfatal stroke, coronary heart disease, congestive heart failure, and cardiovascular death (RR 1.06, 95% CI 0.56-2.04, p=0.85). The myocardial performance index did not predict fatal and nonfatal cardiovascular events (RR 1.06; 95% CI 0.56-2.04; P=0.85) in a high-risk population without overt cardiovascular disease.