What does this research mean for the field?

Concomitant use of cisapride and clarithromycin can induce torsade de pointes ventricular arrhythmia due to a drug interaction involving CYP3A4 inhibition. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To describe a clinical case of torsade de pointes ventricular arrhythmia triggered by an adverse drug-drug interaction between cisapride and clarithromycin.

January 1, 1999Annals of Pharmacotherapy

Torsade De Pointes Induced by Cisapride/Clarithromycin Interaction

View Full Paper

Ask AI

Bookmark

Why the study?

Does concomitant use of cisapride and clarithromycin cause torsade de pointes arrhythmia?

Population

1 patient (77-year-old white woman) admitted with pneumonia and exacerbation of congestive heart failure

Design

Case_report

Follow-up

32 months

Authors

RPRosemary K. PiquetteOttawa Hospital

Discussion

Member takes

Implication

Alerts clinicians to potential TdP risk with this combination; hypothesis-generating for CYP3A4 interaction studies.

Key Points

To describe a clinical case of torsade de pointes ventricular arrhythmia triggered by an adverse drug-drug interaction between cisapride and clarithromycin.
Clinical evaluation of a 77-year-old female receiving cisapride who was co-prescribed clarithromycin and trimethoprim/sulfamethoxazole for pneumonia.
Monitoring of cardiac telemetry, acute therapeutic intervention, medication discontinuation, and patient follow-up over 32 months.
Symptomatic episodes of torsade de pointes arrhythmia manifested within 48 hours following the addition of clarithromycin to maintenance cisapride therapy.
Arrhythmia episodes resolved following antiarrhythmic treatment and cessation of both cisapride and clarithromycin, with zero recurrences documented during 32 months of follow-up.

Structured PICO

Does concomitant use of cisapride and clarithromycin cause torsade de pointes arrhythmia?

Population

1 patient (77-year-old white woman) admitted with pneumonia and exacerbation of congestive heart failure

Intervention

Concomitant use of cisapride and clarithromycin

Outcome

Torsade de pointes ventricular arrhythmiasafety

Concomitant use of cisapride and clarithromycin can induce torsade de pointes due to CYP3A4 inhibition by clarithromycin leading to cisapride accumulation.

Cite This Study

Rosemary K. Piquette (1999) studied this question.

synapsesocial.com/papers/6a1b62f2db618aee6aabd3ac https://doi.org/10.1345/aph.18107

View Full Paper

Ask AI

Bookmark

Torsade De Pointes Induced by Cisapride/Clarithromycin Interaction

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Torsade De Pointes Induced by Cisapride/Clarithromycin Interaction

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider