Key result
Combined cisapride and itraconazole linked to prolonged QT interval and cardiac arrest.
Why the study?
The combination of cisapride and itraconazole may cause cardiac arrest due to drug interactions affecting QT interval prolongation.
Does the combination of cisapride and itraconazole cause cardiac arrest and prolonged QT interval?
Case Report (n=1)
Does the combination of cisapride and itraconazole cause cardiac arrest and prolonged QT interval?
The combination of cisapride and itraconazole can cause prolonged QT interval, torsades de pointes, and sudden cardiac death.
No takes yet. Share an insight, caveat, or question.
Alerts clinicians to possible QT-prolonging interaction in this case; leaves open causality and generalizability pending controlled studies.
Ca et al. (1996) conducted a case report in Cardiac arrest (n=1). Cisapride and itraconazole combination was evaluated on Cardiac arrest and prolonged QT interval. The combination of cisapride and itraconazole was associated with prolonged QT interval and witnessed cardiac arrest in a 31-year-old woman, resolving after withdrawal of both agents.
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