Key result
A highly anti-inflammatory diet was associated with lower heart failure risk in women (HR 0.86; 95% CI 0.78-0.96) and in current (HR 0.86) and ex-smokers (HR 0.81), but not in never-smokers.
Why the study?
The impact of the anti-inflammatory potential of diet on heart failure risk, and potential modification by smoking status, had not been previously investigated.
Does adherence to a diet with high anti-inflammatory potential reduce the risk of incident heart failure in adults without prior cardiovascular disease?
Population
40 514 men and 34 809 women aged 45-83 years without baseline HF, ischaemic heart disease, or cancer
Comparison
Highest quintile vs lowest quintile of the anti-inflammatory diet index
Design
Two prospective cohort studies
Follow-up
Mean follow-up of 14.9 years
Authors
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May lower HF risk among smokers; hypothesis-generating and requires randomized confirmation before practice change.
Cohort (n=75,323)
Does adherence to a diet with high anti-inflammatory potential reduce the risk of incident heart failure in adults without prior cardiovascular disease?
Effect estimate: HR 0.92 (men); HR 0.86 (women) (95% CI 0.84-1.02 (men); 0.78-0.96 (women))
p-value: p=0.02 (men); 0.001 (women)
Adherence to a diet with high anti-inflammatory potential is associated with a lower incidence of heart failure, particularly among current and former smokers.
Kałuża et al. (2020) conducted a cohort in Heart failure (n=75,323). Anti-inflammatory diet (AIDI scores ≥8) vs. Lowest quintile of anti-inflammatory diet index (scores ≤4) was evaluated on Heart failure incidence (HR 0.92 (men); HR 0.86 (women), 95% CI 0.84-1.02 (men); 0.78-0.96 (women), p=0.02 (men); 0.001 (women)). A highly anti-inflammatory diet was associated with lower heart failure risk in women (HR 0.86; 95% CI 0.78-0.96) and in current (HR 0.86) and ex-smokers (HR 0.81), but not in never-smokers.