Key result
Fasting blood sugar was the only clinical parameter significantly associated with severe coronary stenosis (≥70%) among newly diagnosed ischemic heart disease patients (p=0.002).
Why the study?
The study aimed to evaluate whether common parameters from preliminary non-invasive CAD testing associate with the severity of coronary artery stenosis in newly diagnosed IHD patients.
Are common demographic and clinical parameters associated with severe coronary artery stenosis in newly diagnosed IHD patients?
Case-Control (n=80)
Are common demographic and clinical parameters associated with severe coronary artery stenosis in newly diagnosed IHD patients?
p-value: p=0.002
Fasting blood sugar is significantly associated with severe coronary stenosis, while the Framingham risk score may underestimate risk in newly diagnosed IHD patients.
The number of death due to ischemic heart disease (IHD) keep increasing every year and it is usually caused by coronary artery disease (CAD). Early diagnosis of CAD requires a combination of multiple tests including a 12-lead ECG test, blood test, and stress test before the patient can go through a more complex procedure such as coronary computed tomography angiography or invasive coronary angiography procedure. The study aims to investigate the association between common parameters from the preliminary test of CAD to the severity of stenosis in the coronary arteries among newly diagnosed IHD patients. A total of 80 CAD patients (55 ± 9.52 years) have participated in this study and their demographic data, vital signs, blood tests, as well as ECG result are taken just before they are going for the angiography procedure. It was found that 75% of the subjects are overweight. The results also showed that the number of patients who smoke, have diabetes, and have hypertension is higher in the case group (stenosis ≥ 70%) as compared to the control group (stenosis < 70%). There was no clinical data that can differentiate severe stenosis in the coronary arteries, except for fasting blood sugar (p=0.002). Subjects with severely blocked arteries tend to have higher levels of blood sugar with a mean of 8.05 ± 3.60. Framingham risk scores (FRS) for both groups were also compared, and it is found that 59% of the total subjects have low FRS, even though half of them have severe stenosis. Thus, a technical approach is required to determine the stenosis level in the coronary arteries. The application of non-invasive techniques such as electrocardiogram and photoplethysmogram is preferable for this purpose.
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Suboh et al. (2023) conducted a case-control in Ischemic Heart Disease (IHD) / Coronary Artery Disease (CAD) (n=80). Clinical and demographic parameters (including fasting blood sugar) vs. Stenosis < 70% (control group) was evaluated on Severe stenosis in the coronary arteries (≥ 70%) (p=0.002). Fasting blood sugar was the only clinical parameter significantly associated with severe coronary stenosis (≥70%) among newly diagnosed ischemic heart disease patients (p=0.002).
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