Key result
In patients with NSTEMI and elevated troponin-I levels, 83.75% had extent of coronary artery disease findings on angiography, with single, two, and three-vessel disease observed in 25.25%, 37.75%, and 20% of cases respectively.
Why the study?
Patients with troponin levels >10-fold upper normal limits are considered high risk, with potential association with extensive three-vessel CAD involvement in NSTEMI.
Is a Troponin-I level >10 folds the upper limit of normal associated with the extent of coronary artery disease in patients with NSTEMI?
Cross-Sectional (n=800)
No
Is a Troponin-I level >10 folds the upper limit of normal associated with the extent of coronary artery disease in patients with NSTEMI?
Markedly elevated Troponin-I levels in NSTEMI patients are strongly associated with multi-vessel coronary artery disease, supporting early invasive assessment.
Elevated troponin-I was associated with multi-vessel CAD in NSTEMI; hypothesis-generating and requires prospective validation before guiding risk stratification.
Introduction: Higher levels of troponins >10 folds of upper normal limits (UNL) are considered as high-risk patients on coronary angiography sufferers having high levels of troponin-I (>10 folds upper limit normal level) had extra three-vessel coronary artery disease involvement. Objectives: To determine the frequency of degree of cardiovascular disease with Troponin-I level >10 folds ULN in NSTEMI patients at tertiary care hospital. Methodology: It is a cross-sectional study comprising of a total 800 patients recruited from the Department of Cardiology, National Institute of Coronary Disease, Karachi Pakistan based on Exclusion/Inclusion criteria. Results: There are 678 male as well as 122 female patients. The mean troponin-I level was 15.00±6.82 ng/ml. Single vessel disease found in 25.25% cases, two vessel diseases were observed in 37.75% cases, and three vessel diseases were observed in 20% cases. 83% were found with extent of CAD findings on angiography. There have been 678 male and also 122 female patients. The mean troponin-I level was 15.00±6.82 ng/ml. Single vessel disease found in 25.25% cases, two vessel diseases were observed in 37.75% cases, and three vessel diseases were observed in 20% cases. 83% were found with extent of CAD findings on angiography. Conclusion: The higher troponin level found significantly associated with extent of CAD and three vessel disease. To understand the cardiovascular troponin condition of the sufferer as soon as feasible is crucial.
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Kumar et al. (2021) conducted a cross-sectional in Non-ST-segment elevation myocardial infarction (NSTEMI) (n=800). Troponin-I level >10 folds ULN was evaluated on Frequency of extent of coronary artery disease (CAD) findings on angiography. In patients with NSTEMI and elevated troponin-I levels, 83.75% had extent of coronary artery disease findings on angiography, with single, two, and three-vessel disease observed in 25.25%, 37.75%, and 20% of cases respectively.
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