Key result
Higher hs-TnI predicts ~102% greater death and combined event risk in stable CAD.
Why the study?
Although troponin levels are linked to adverse outcomes in chronic conditions, it was unclear whether troponin levels from unselected outpatient blood samples are associated with adverse outcomes in stable coronary artery disease.
Are high-sensitivity troponin I levels associated with adverse outcomes in patients with stable coronary artery disease?
Cohort (n=949)
Are high-sensitivity troponin I levels associated with adverse outcomes in patients with stable coronary artery disease?
Hazard Ratio: 2.02 (95% CI 1.13–3.6)
p-value: p=0.017
In patients with stable coronary artery disease, high-sensitivity troponin I levels are independently associated with an increased risk of death and heart failure hospitalization over a medium-term follow-up.
May aid risk stratification in stable CAD; extends observational data but leaves therapeutic implications open.
Numerous studies have been published suggesting that troponin levels are related to adverse outcomes in chronic cardiac and non-cardiac conditions. Our study investigated whether troponin levels gathered from unselected blood samples taken during outpatient care are associated with adverse outcomes in a population with stable coronary artery disease. In a cohort of 949 patients with stable coronary artery disease, an average age of 67.5 ± 9.5 years, 69.5% male, 52.1% diabetics, 51.6% with previous myocardial infarction, and 57.9% with triple-vessel disease, 21.7% of patients encountered new events during an average period of monitoring of 2.07 ± 0.81 years. Troponin I/99th percentile categorized into tertiles emerged as an independent predictor of death and combined events risk (hazard ratio: 2.02 (1.13–3.60), p = 0.017; 2.30 (1.37–3.88, p = 0.002, respectively). A troponin ratio > 0.24 was able to identify 53.3% of patients at risk of death and heart failure hospitalization. In patients with stable coronary artery disease who are adherent to treatment, troponin levels are independently associated with death and heart failure hospitalization in a medium-term follow-up.
No takes yet. Share an insight, caveat, or question.
Strunz et al. (2023) conducted a cohort in Stable coronary artery disease (n=949). High-sensitivity Troponin I levels vs. Lower troponin levels (tertiles) was evaluated on Death (HR 2.02, 95% CI 1.13-3.60, p=0.017). Higher high-sensitivity Troponin I levels independently predicted an increased risk of death (HR 2.02; 95% CI 1.13-3.60; p=0.017) and combined events in patients with stable coronary artery disease.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: