Peak steps to measure ‘‘capacity for activity’’: Actigraphy in the ADAPT registry with oral treprostinil

Figures

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  Figure 1. Changes in peak steps between Visit 1 and 2. (A–D) Peak 3–20 minutes steps increased with oral treprostinil treatment. The Oral Treprostinil Naïve Group (n = 5) is denoted by triangles and the Oral Treprostinil Exposed Group (n = 8) is denoted by circles. Each of the 13 participants is denoted by a letter. Peak steps are a mean over the days worn immediately after each study visit.

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  Figure 2. Six-minute walk distance (6MWD) and emPHasis-10 correlate with total daily steps and 5-minute peak steps at Visit 1. (A,B) Both baseline total daily steps and peak 5-minute steps have a strong positive correlation with 6MWD at Visit 1. (C) Moderate activity did not correlate with 6MWD at visit 1. (D,E) Total daily steps and peak 5-minute steps have a strong negative correlation with emPHasis-10 at Visit 1. (F) Moderate activity time did not correlate with emPHasis-10 at Visit 1. Total daily steps, peak 5-minute steps, and moderate activity time are a mean over the days worn immediately after the baseline study visit.