Key result
Vitamin D supplementation in critically ill patients decreased the duration of mechanical ventilation and ICU stay, but did not significantly reduce mortality (RR 0.85).
Why the study?
Randomized controlled trials have reported conflicting outcomes with the use of vitamin D in critically ill patients, prompting an updated meta-analysis following the publication of newer trials.
Does vitamin D supplementation reduce mortality, duration of mechanical ventilation, and length of stay in critically ill patients?
Comparison
Vitamin D vs placebo
Design
Random-effects meta-analysis of RCTs
Authors
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May shorten ventilation and ICU stay in critical illness; extends meta-analytic support for secondary outcomes while leaving mortality benefit unconfirmed.
Meta-Analysis (n=2,187)
Does vitamin D supplementation reduce mortality, duration of mechanical ventilation, and length of stay in critically ill patients?
Effect estimate: RR 0.85 (95% CI 0.68, 1.04)
p-value: p=0.12
Vitamin D supplementation in critically ill patients reduces the duration of mechanical ventilation and ICU stay, with subgroup analysis suggesting potential mortality benefits with parenteral administration.
Singh et al. (2022) conducted a meta-analysis in Critically ill patients admitted to the intensive care unit (ICU) (n=2,187). Vitamin D vs. Placebo was evaluated on Mortality (RR 0.85, 95% CI 0.68, 1.04, p=0.12). Vitamin D supplementation in critically ill patients decreased the duration of mechanical ventilation and ICU stay, but did not significantly reduce mortality (RR 0.85).
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