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August 31, 2020Scientific ReportsOpen Access

No significant difference was observed in 28-day mortality between the vitamin D supplementation and placebo groups (20.4% vs 21.7%, OR 0.73; 95% CI 0.46–1.15; I² = 51%).

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Why the study?

This meta-analysis was conducted to assess the association between vitamin D supplementation and outcomes in critically ill adult patients.

Does vitamin D supplementation reduce 28-day mortality in critically ill adult patients?

Population

1867 critically ill adult patients across 9 RCTs

Comparison

Vitamin D supplementation vs placebo

Design

Systematic review and meta-analysis of randomized controlled trials

Authors

SLShao‐Huan LanCLChih‐Cheng LaiSCShen-Peng Chang

Discussion

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Overview

Vitamin D offers no mortality or length-of-stay benefit in critically ill adults; reinforces against routine supplementation and narrows future trials to deficient subgroups.

Structured PICO

Does vitamin D supplementation reduce 28-day mortality in critically ill adult patients?

P
Population
1,867 critically ill adult patients pooled from 9 RCTs
I
Intervention
Vitamin D supplementation (enteral, intramuscular, or intravenous route; high or low dose)
C
Comparator
Placebo
O
Outcome
28-day mortalityhard clinical

Vitamin D supplementation does not provide a mortality benefit or improve clinical outcomes such as ICU stay or mechanical ventilation duration in critically ill adult patients compared to placebo.

Cite This Study

Lan et al. (2020) studied this question.

synapsesocial.com/papers/6a79663602ab7a73dd02535ehttps://doi.org/10.1038/s41598-020-71271-9
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Vitamin D Supplementation in Critically Ill Patients: A Meta-Analysis of Randomized Controlled Trials2022 · 18 citations
  2. 2P-1586. Safety and Efficacy of Vitamin D3 in the Management of COVID-19: A Systematic Review and Meta-Analysis2026
  3. 3Effect of High-Dose Vitamin D on Mortality and Hospital Length of Stay in ICU Patients with COVID-19: A Randomized Clinical Trial2024 · 2 citations
  4. 4Effect of Vitamin D3 Supplementation on Severe COVID-19: A Meta-Analysis of Randomized Clinical Trials2024 · 13 citations
  5. 5Clinical Outcome of Vitamin D Supplementation in Moderate and Severe COVID-19 Patients: A Randomized Clinical Trial2024