Why the study?
Does failure to maintain low ADP concentration contribute to diastolic dysfunction in hypertrophied rat hearts?
Does failure to maintain low ADP concentration contribute to diastolic dysfunction in hypertrophied rat hearts?
Increased intracellular ADP contributes to diastolic dysfunction in left ventricular hypertrophy, likely due to slowed cross-bridge cycling and decreased creatine kinase reaction capacity.
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Elevated ADP may contribute to diastolic dysfunction in LVH; leaves open whether ADP-targeted therapies warrant human investigation.
Tian et al. (1997) studied this question.
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