Why the study?
Does failure to maintain low ADP concentration contribute to diastolic dysfunction in hypertrophied rat hearts?
Population
Isolated rat hearts, aortic-banded (LVH, n=5) and sham-operated (control, n=5)
Comparison
Perfusion with pyruvate and 2-deoxyglucose to… vs Sham-operated rat hearts perfused with the same
Design
Preclinical
Authors
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Elevated ADP may contribute to diastolic dysfunction in LVH; leaves open whether ADP-targeted therapies warrant human investigation.
Does failure to maintain low ADP concentration contribute to diastolic dysfunction in hypertrophied rat hearts?
Increased intracellular ADP contributes to diastolic dysfunction in left ventricular hypertrophy, likely due to slowed cross-bridge cycling and decreased creatine kinase reaction capacity.
Tian et al. (1997) studied this question.
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