Diastolic Dysfunction in Hypertensive Heart Disease Is Associated With Altered Myocardial Metabolism
Why the study?
Is myocardial high-energy phosphate metabolism altered in patients with hypertensive heart disease and associated with left ventricular diastolic dysfunction?
Population
24 subjects (11 patients with hypertension and 13 age-matched healthy subjects)
Design
Case-control
Authors
Discussion
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Member takes
Implication
May link energetics to diastolic dysfunction in hypertension; hypothesis-generating for causal and interventional studies.
Structured PICO
Is myocardial high-energy phosphate metabolism altered in patients with hypertensive heart disease and associated with left ventricular diastolic dysfunction?
P
Population
24 subjects (11 patients with hypertension and 13 age-matched healthy subjects)
C
Comparator
Age-matched healthy control subjects
O
Outcome
Myocardial phosphocreatine (PCr)/ATP ratio at rest and during high-dose atropine-dobutamine stresssurrogate
Patients with hypertensive heart disease exhibit altered myocardial high-energy phosphate metabolism, which correlates with impaired left ventricular diastolic function.
Cite This Study
Lamb et al. (1999) studied this question.