Why the study?
Does hypertrophic cardiomyopathy or aging alter myocardial high-energy phosphate metabolism as measured by 31P MRS?
Population
30 normal volunteers, patients with hypertension, and 10 patients with hypertrophic cardiomyopathy, compared…
Comparison
Quantitative measurement of high-energy… vs Age-matched normal controls
Design
Cross-sectional
Authors
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Suggests energetic impairment in HCM; hypothesis-generating for 31P MRS as a biomarker before clinical use.
Does hypertrophic cardiomyopathy or aging alter myocardial high-energy phosphate metabolism as measured by 31P MRS?
Quantitative 31P MRS demonstrates that hypertrophic cardiomyopathy and aging are associated with significant reductions in myocardial high-energy phosphates (PCr and ATP).
Okada et al. (1998) studied this question.
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