What does this research mean for the field?

The renin-angiotensin system in heart failure drives maladaptive myocardial remodeling, altered calcium homeostasis, and endothelial dysfunction, extending its pathophysiological role far beyond simple hemodynamic overload. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 1993

Pathophysiology of heart failure and the renin-angiotensin-system

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Population

Patients with heart failure

Design

Review

Authors

JHJ. HoltzUniversity of Pittsburgh Medical Center

Discussion

Member takes

Implication

Broadens RAS blockade rationale in HF beyond hemodynamics; leaves open whether targeting neuroendocrine or gene effects improves outcomes.

Structured PICO

Population

Patients with heart failure

Intervention

Inhibition of the renin-angiotensin system (ACE-inhibition)

This review highlights that ACE-inhibition in heart failure provides benefits beyond vasodilation by attenuating neuroendocrine activity and preventing adverse myocardial remodeling.

Cite This Study

J. Holtz (1993) studied this question.

synapsesocial.com/papers/6a1b7f3839ea7417dc42e825 https://doi.org/10.1007/978-3-642-72497-8_13

Topics

Heart failure HFrEF treatment

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Implication

Broadens RAS blockade rationale in HF beyond hemodynamics; leaves open whether targeting neuroendocrine or gene effects improves outcomes.

Pathophysiology of heart failure and the renin-angiotensin-system

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Pathophysiology of heart failure and the renin-angiotensin-system

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider