Key result
Depressive disorders were associated with a significantly increased risk of new-onset hip fractures compared to matched controls without depressive disorders (HR 1.34).
Why the study?
Do depressive disorders increase the risk of new-onset hip fractures in a nationwide population?
Cohort (n=22,414)
Do depressive disorders increase the risk of new-onset hip fractures in a nationwide population?
Depressive disorders are independently associated with a significantly increased risk of new-onset hip fractures, particularly in older patients and those with comorbidities or low socioeconomic status.
Answers are grounded in this paper and cite their sources.
Depressive disorders may warrant hip fracture vigilance in older patients; leaves open causality and needs prospective confirmation.
BACKGROUND: Some studies have suggested that depressive disorders may play a vital role in the incidence of hip fractures. However, nationwide data are lacking regarding the association between depressive disorders and hip fractures. OBJECTIVE: We aimed to explore the association between depressive disorders and new-onset hip fractures. METHODS: We conducted a retrospective study of 11,207 patients with depressive disorders and 11,207 control patients using Taiwan's National Health Insurance Research Database. A Cox regression model was used to evaluate the risk of hip fractures in patients with depressive disorders. RESULTS: The incidence rate ratio of hip fractures between patients with depressive disorders and controls was 1.6 (95% confidence interval [CI] = 1.29-1.99, P < .001). After adjustment for potential confounders in multivariate analysis using the Cox regression model, patients with depressive disorders were found to have 1.34 times higher risk of hip fractures than controls (95% CI = 1.08-1.66, P = .008). Furthermore, age (hazard ratio [HR] = 7.43, 95% CI = 4.94-11.19, P < .001), hypertension (HR = 1.63, 95% CI = 1.17-2.28, P = .004), diabetes mellitus (HR = 1.47, 95% CI = 1.08-1.99, P = .014), cerebrovascular disease (HR = 1.76, 95% CI = 1.31-2.35, P < .001), living in rural areas (HR = 1.88, 95% CI = 1.30-2.70, P = .001), and low monthly income (NT$0-NT$19,000: HR = 4.08, 95% CI = 1.79-9.29, P = .001 and NT$19,100-NT$42,000: HR = 4.09, 95% CI = 1.76-9.49, P = .001) were independent risk factors for new-onset hip fractures in patients with depressive disorders. CONCLUSION: Depressive disorders might increase the risk of new-onset hip fractures, particularly in older patients and patients with hypertension, diabetes mellitus, cerebrovascular disease, or low socioeconomic status.
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Pan et al. (2018) conducted a cohort in Depressive disorders (n=22,414). Depressive disorders vs. Matched controls without depressive disorders was evaluated on New-onset hip fractures (HR 1.34, 95% CI 1.08-1.66, p=0.008). Depressive disorders were associated with a significantly increased risk of new-onset hip fractures compared to matched controls without depressive disorders (HR 1.34).
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