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December 14, 2009Lara D. VeekenOpen Access

Development and initial validation of the Localized Scleroderma Skin Damage Index and Physician Global Assessment of disease Damage: a proof-of-concept study

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To develop and validate the Localized Scleroderma Skin Damage Index and Physician Global Assessment of disease damage.
Evaluated 30 localized scleroderma patients and 112 lesions using two assessment tools.
Eight rheumatologists assessed 17 variables for tool formulation.
Measured skin changes at 18 anatomical sites to calculate LoSDI scores.
LoSDI and its domains (dermal atrophy, subcutaneous atrophy, dyspigmentation) showed excellent inter-rater reliability (0.86-0.99) and intra-rater reliability (0.74-0.96).
LoSDI correlated moderately with PGA-D and poorly with PtGA-S and CDLQI.
PGA-D correlated moderately with PtGA-S but poorly with CDLQI.

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Proof-of-concept study evaluates skin damage index and physician assessment in localized scleroderma patients, indicating high reliability.

Arkachaisri et al. (2009) studied this question.

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Proof-of-concept study evaluates skin damage index and physician assessment in localized scleroderma patients, indicating high reliability.