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August 19, 2026Pediatric RheumatologyOpen Access

Cross-cultural adaptation and validation of the Localised Scleroderma Quality of Life Instrument (LoSQI): an international study

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To perform cross-cultural adaptation and international validation of the Localised Scleroderma Quality of Life Instrument (LoSQI), a disease-specific quality of life measure for juvenile localised scleroderma.
Conducted Phase I cross-cultural adaptation via forward/backward translation and cognitive debriefing interviews across 16 languages (N=162 across 20 sites).
Performed Phase II psychometric validation (N=213 across 36 sites; total study N=236 with 139 participating in both phases) using confirmatory factor analysis, item-level analysis, and construct validity testing against the Children's Dermatology Life Quality Index and physician-reported disease activity.
Successfully adapted the instrument into 16 languages, with 97% of participants endorsing instrument utility and 95% reporting ease of completion.
Confirmatory factor analysis supported a two-subscale model: Pain and Physical Functioning, and Body Image and Social Support.
Demonstrated construct validity via moderate-to-strong correlations between both LoSQI subscales and skin-specific HRQoL (CDLQI), with weak or absent correlations to physician-reported clinical disease activity.

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Implication

Multicenter validation study demonstrates robust measurement properties for the translated LoSQI in juvenile localised scleroderma, supporting international quality of life assessment.

Cite This Study

Zigler et al. (2026) studied this question.

synapsesocial.com/papers/6a85637603308d306e2d6a92 https://doi.org/10.1186/s12969-026-01257-w

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Implication

Multicenter validation study demonstrates robust measurement properties for the translated LoSQI in juvenile localised scleroderma, supporting international quality of life assessment.

Cross-cultural adaptation and validation of the Localised Scleroderma Quality of Life Instrument (LoSQI): an international study

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Discussion

Implication

Cite This Study

Cross-cultural adaptation and validation of the Localised Scleroderma Quality of Life Instrument (LoSQI): an international study

Key Points

Discussion

Implication

Cite This Study

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