What does this research mean for the field?

There is no strong linear association between blood pressure and cognitive decline in the elderly; rather, the relationship is complex and U-shaped, with both elevated and low blood pressure associated with worse cognitive performance. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

February 3, 1999JAMA

Current and Remote Blood Pressure and Cognitive Decline

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Why the study?

Does blood pressure level predict cognitive decline in the elderly?

Population

3,657 elderly subjects aged 65 to 102 years enrolled in the East Boston component of the Established…

Comparison

Blood pressure levels vs Referent blood pressure group

Design

Cohort

Follow-up

6 years

Authors

RGRobert J. GlynnGeneral / Preventive / Lipids

Discussion

Member takes

Implication

Prior elevated systolic BP may flag higher cognitive error risk in elderly; extends midlife BP-cognition links but leaves causal effects open.

Structured PICO

Does blood pressure level predict cognitive decline in the elderly?

Population

3,657 elderly subjects aged 65 to 102 years enrolled in the East Boston component of the Established Populations for the Epidemiologic Study of the Elderly (EPESE), with 2,068 also participating in the Hypertension Detection and Follow-Up Program (HDFP) 9 years prior.

Intervention

Blood pressure levels (current and remote/9 years prior)

Comparator

Referent blood pressure group (systolic 130-139 mm Hg)

Outcome

Numbers of errors on the Short Portable Mental Status Questionnaire and the East Boston Memory Test and rates of change in these numbers of errors at 3 and 6 yearssurrogate

Blood pressure has a complex, non-linear (U-shaped) association with cognitive function in the elderly, with both low and high systolic BP associated with increased errors on mental status questionnaires.

Cite This Study

Robert J. Glynn (1999) studied this question.

synapsesocial.com/papers/6a1ba4530ea968f653ac0f1b https://doi.org/10.1001/jama.281.5.438

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February 3, 1999JAMA

Current and Remote Blood Pressure and Cognitive Decline

View Full Paper

Ask AI

Bookmark

Why the study?

Does blood pressure level predict cognitive decline in the elderly?

Population

3,657 elderly subjects aged 65 to 102 years enrolled in the East Boston component of the Established…

Comparison

Blood pressure levels vs Referent blood pressure group

Design

Cohort

Follow-up

6 years

Authors

RGRobert J. GlynnGeneral / Preventive / Lipids

Discussion

Member takes

Implication

Prior elevated systolic BP may flag higher cognitive error risk in elderly; extends midlife BP-cognition links but leaves causal effects open.

Structured PICO

Does blood pressure level predict cognitive decline in the elderly?

Population

Intervention

Blood pressure levels (current and remote/9 years prior)

Comparator

Referent blood pressure group (systolic 130-139 mm Hg)

Outcome

Numbers of errors on the Short Portable Mental Status Questionnaire and the East Boston Memory Test and rates of change in these numbers of errors at 3 and 6 yearssurrogate

Cite This Study

Robert J. Glynn (1999) studied this question.

synapsesocial.com/papers/6a1ba4530ea968f653ac0f1b https://doi.org/10.1001/jama.281.5.438

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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