Homeostasis in Mice with Genetically Decreased Angiotensinogen Is Primarily by an Increased Number of Renin-producing Cells
Population
Mice having one angiotensinogen gene inactivated
Comparison
Genetic inactivation of one angiotensinogen gene vs Wild-type mice
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Should not change clinical RAS management; extends murine models of angiotensinogen feedback via renin cell hyperplasia.
Structured PICO
P
Population
Mice having one angiotensinogen gene inactivated
I
Intervention
Genetic inactivation of one angiotensinogen gene
C
Comparator
Wild-type mice
O
Outcome
Biochemical, molecular, and cellular changes in the endocrine branch of the renin-angiotensin system directed toward blood pressure homeostasissurrogate
In mice with decreased angiotensinogen, homeostasis is maintained by increasing the number of renin-producing cells rather than up-regulating renin production in existing cells.
Cite This Study
Kim et al. (1999) studied this question.