What question did this study set out to answer?

To determine whether cigarette smoking induces structural remodeling in muscular pulmonary arteries and to evaluate how these changes relate to airway pathology and emphysema.

August 1, 1980

Morphologic changes in the muscular pulmonary arteries: relationship to cigarette smoking, airway disease, and emphysema.

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Authors

KHKathryn HaleAbbott Northwestern Hospital DNDennis E. NiewoehnerUniversity of Minnesota MCManuel G. CosíoUniversity of Padua

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Implication

Morphometric study demonstrates arterial remodeling in long-term smokers, indicating a structural link to small airway disease, emphysema, and potential pulmonary hypertension.

Key Points

To determine whether cigarette smoking induces structural remodeling in muscular pulmonary arteries and to evaluate how these changes relate to airway pathology and emphysema.
Examined muscular pulmonary arteries (< 500 µm external diameter) via morphometric analysis in 25 long-term cigarette smokers and 14 lifelong nonsmokers.
Measured external diameter, medial smooth muscle thickness, and intimal thickness, assessing correlations with small airway disease severity, emphysema degree, and bronchial mucous gland enlargement.
Smokers demonstrated a significantly higher count of transected muscular arteries < 200 µm (p < 0.03), increased medial smooth muscle (p < 0.02), and increased intimal thickening (p < 0.04) versus nonsmokers.
Vascular remodeling correlated significantly with both the severity of small airway disease and the degree of emphysema, but not with bronchial mucous gland enlargement.

Cite This Study

Hale et al. (1980) studied this question.

synapsesocial.com/papers/6a1bc2554ebd09f3dfa8f3cd https://doi.org/10.1164/arrd.1980.122.2.273

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Implication

Morphometric study demonstrates arterial remodeling in long-term smokers, indicating a structural link to small airway disease, emphysema, and potential pulmonary hypertension.

Morphologic changes in the muscular pulmonary arteries: relationship to cigarette smoking, airway disease, and emphysema.

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Key Points

Cite This Study

Morphologic changes in the muscular pulmonary arteries: relationship to cigarette smoking, airway disease, and emphysema.

Discussion

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Implication

Key Points

Cite This Study

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