April 1, 2002European Respiratory JournalOpen Access

Characterization of pulmonary vascular remodelling in smokers and patients with mild COPD

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Population

Lung specimens from patients with moderate COPD and smokers without airflow obstruction.

Design

Cross-sectional

Authors

SSSalud SantosInstituto de Salud Carlos III VPVíctor I. PeinadoCentre for Biomedical Network Research on Rare Diseases JRJosé RamírezMedical University of Lublin

Discussion

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Implication

May indicate early vascular remodeling in smokers; hypothesis-generating for progression and intervention targets.

Structured PICO

Population

Lung specimens from patients with moderate COPD (n=8; FEV1 66 +/- 10% predicted) and smokers without airflow obstruction (n=7; FEV1 86 +/- 6% predicted).

Outcome

Characterization of structural changes (cellular and extracellular components) in pulmonary muscular arteriessurrogate

Pulmonary vascular remodeling, characterized by smooth muscle cell proliferation and extracellular matrix deposition, occurs early in cigarette smoke-induced respiratory disease even before significant airflow obstruction.

Cite This Study

Santos et al. (2002) studied this question.

synapsesocial.com/papers/69d56ee875589c71d767d799 https://doi.org/10.1183/09031936.02.00245902

View Full Paper

Ask AI

Bookmark

Characterization of pulmonary vascular remodelling in smokers and patients with mild COPD

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Characterization of pulmonary vascular remodelling in smokers and patients with mild COPD

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider