Key result
Cigarette smoking and mild COPD were associated with increased CD8+ T-lymphocyte infiltrate in pulmonary arteries and impaired endothelium-dependent relaxation compared to nonsmokers.
Why the study?
Is cigarette smoking and mild COPD associated with increased inflammatory cell infiltrate and impaired endothelium-dependent relaxation in pulmonary arteries?
Observational (n=39)
Is cigarette smoking and mild COPD associated with increased inflammatory cell infiltrate and impaired endothelium-dependent relaxation in pulmonary arteries?
Cigarette smoking induces a CD8+ T-lymphocyte infiltrate in pulmonary arteries associated with impaired vessel structure and function, suggesting inflammation plays a role in early COPD pulmonary vascular abnormalities.
No takes yet. Share an insight, caveat, or question.
No immediate practice change; hypothesis-generating for CD8+ inflammation in early COPD vascular disease.
Peinado et al. (1999) conducted an observational in Mild chronic obstructive pulmonary disease (COPD) (n=39). Tobacco smoking vs. Nonsmokers was evaluated on Inflammatory cell infiltrate and endothelium-dependent relaxation in pulmonary arteries. Cigarette smoking and mild COPD were associated with increased CD8+ T-lymphocyte infiltrate in pulmonary arteries and impaired endothelium-dependent relaxation compared to nonsmokers.
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