Why the study?
The mechanisms by which sodium channel blockade and high-rate pacing modify electrogram substrates of Brugada syndrome had not been elucidated.
Does ajmaline administration and high-rate pacing modify the electrogram substrates in patients with Brugada syndrome?
Does ajmaline administration and high-rate pacing modify the electrogram substrates in patients with Brugada syndrome?
Sodium channel blockade with ajmaline and high-rate pacing exacerbate conduction delays and fractionated electrograms in fibrotic right ventricular outflow tract substrates, providing a mechanism for arrhythmogenesis in Brugada syndrome.
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Ajmaline and high-rate pacing expand Brugada substrates; supports mechanistic role in arrhythmogenesis but leaves open clinical translation.
Nademanee et al. (2021) studied this question.
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