Why the study?
In-vivo imaging cannot yield detailed Purkinje network structures, and direct fractal-tree algorithms incorrectly model clinical ECGs and activation sequences in complex geometries.
Population
39 healthy male individuals from the PTB diagnostic database
Comparison
Two-stage Purkinje network model vs observed activation sequences and ECGs
Design
In-silico modeling study
Authors
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May advance in silico cardiac modeling; leaves open human validation before any clinical use.
A novel two-stage computational method for generating Purkinje networks produces anatomically and physiologically plausible ECGs and activation sequences.
Shalaby et al. (2020) studied this question.
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