Why the study?
How do different general anesthetics compare in their effects on myocardial contractility in isolated cat papillary muscles?
Population
Isolated cat papillary muscles driven at a rate of 12 beats/min at 37.5 C
Comparison
Exposure to concentrations of cyclopropane… vs Comparison among the five anesthetics at…
Design
Preclinical
Authors
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Animal data on anesthetic potency in isolated muscle warrant caution; leaves open human translation.
How do different general anesthetics compare in their effects on myocardial contractility in isolated cat papillary muscles?
General anesthetics depress myocardial contractility in a qualitatively similar manner, but with varying degrees of potency at equieffective anesthetic concentrations.
Brown et al. (1971) studied this question.
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