Why the study?
Do volatile anesthetics (isoflurane, enflurane, halothane) depress myocardial contractility in rat and frog ventricular myocardium?
Population
Rat right ventricular papillary muscles and frog ventricular strips
Comparison
Volatile anesthetics vs Control (absence of anesthetics)
Design
Preclinical
Authors
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Animal data should not alter clinical anesthetic selection; leaves open translational validation in humans.
Do volatile anesthetics (isoflurane, enflurane, halothane) depress myocardial contractility in rat and frog ventricular myocardium?
Halothane is more potent than isoflurane in depressing myocardial contractility in both rat and frog ventricular myocardium, likely by reducing Ca2+ release from the sarcoplasmic reticulum and depressing extracellular Ca2+ entry.
Martha J. Frazer (1989) studied this question.
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