Key result
Isoflurane depressed peak tension and dT/dt max significantly less at high frequencies than did equivalent doses of halothane in isolated guinea pig papillary muscle.
Why the study?
Does isoflurane depress myocardial contractility differently than halothane in isolated guinea pig papillary muscle?
Population
Isolated right ventricular guinea pig papillary muscle bathed in Tyrode's solution at 37 degrees C
Comparison
Isoflurane and enflurane vs Halothane (0.75% or 1.5%)
Design
Preclinical
Authors
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Animal findings warrant no practice change; leaves open translation of frequency-dependent effects to human myocardium.
Does isoflurane depress myocardial contractility differently than halothane in isolated guinea pig papillary muscle?
Isoflurane alters the pattern of tension development differently than halothane in isolated guinea pig papillary muscle, suggesting different mechanisms of myocardial depression.
Carl Lynch (1986) studied this question. Isoflurane vs. Halothane and enflurane was evaluated on Peak tension and dT/dt max. Isoflurane depressed peak tension and dT/dt max significantly less at high frequencies than did equivalent doses of halothane in isolated guinea pig papillary muscle.
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