Key result
In the absence of ryanodine, 0.6% halothane depressed contractile force of isolated rabbit atria by 32% vs 16% in low Ca2+ media, whereas isoflurane caused minimal to no inhibition.
Why the study?
Do halothane and isoflurane directly affect the function of the sarcoplasmic reticulum and force of contraction in isolated rabbit atria?
Population
Isolated rabbit atria
Comparison
Halothane or isoflurane in normal Ca2+ medium… vs Low Ca2+ media without anesthetic
Design
Preclinical
Authors
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Halothane may depress rabbit atrial contractility via SR calcium release more than isoflurane; leaves open translation to human or in vivo cardiac function.
Do halothane and isoflurane directly affect the function of the sarcoplasmic reticulum and force of contraction in isolated rabbit atria?
Absolute Event Rate: 32% vs 16%
Halothane significantly depresses contractile force dependent on sarcoplasmic reticulum calcium release in rabbit atria, whereas isoflurane has minimal to no such effect.
Komai et al. (1990) studied this question. Halothane and isoflurane vs. Low Ca2+ media without anesthetic was evaluated on Force of contraction depression. In the absence of ryanodine, 0.6% halothane depressed contractile force of isolated rabbit atria by 32% vs 16% in low Ca2+ media, whereas isoflurane caused minimal to no inhibition.
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