May 1, 1986Anesthesia & Analgesia
Intracellular Mechanism of Action of Isoflurane and Halothane on Striated Muscle of the Rabbit
Population
Functionally skinned muscle fibers from isolated papillary muscle, soleus, and adductor magnus of rabbits
Comparison
Isoflurane (1-4%) and halothane (1-3%) vs Control solution (saturated with N2)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Should not yet change anesthetic practice; hypothesis-generating for Ca2+ mechanisms in volatile anesthetic cardiotoxicity.
Structured PICO
P
Population
Functionally skinned muscle fibers from isolated papillary muscle (PM), soleus (SL) (slow-twitch skeletal muscle), and adductor magnus (AM) (fast-twitch skeletal muscle) of rabbits
I
Intervention
Isoflurane (1-4%) and halothane (1-3%)
C
Comparator
Control solution (saturated with N2)
O
Outcome
Ca2+-activated tension development of the contractile proteins and Ca2+ uptake and release from the sarcoplasmic reticulumsurrogate
Isoflurane and halothane alter intracellular Ca2+ handling and tension development in striated muscle, which may contribute to decreased myocardial contractility and increased skeletal muscle contraction.
Cite This Study
Su et al. (1986) studied this question.