Why the study?
Do halothane and isoflurane decrease Ca2+ sensitivity and maximal force in human skinned cardiac fibers?
Population
Left ventricular muscle strips (skinned cardiac fibers) obtained from 7 patients undergoing cardiac surgery
Comparison
Halothane and isoflurane vs Control (no anesthetic)
Design
Preclinical
Authors
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May contribute to volatile anesthetic negative inotropy; leaves open direct effects in human cardiac fibers.
Do halothane and isoflurane decrease Ca2+ sensitivity and maximal force in human skinned cardiac fibers?
Halothane and isoflurane directly decrease calcium sensitivity and maximal force in human cardiac fibers, which may contribute to their negative inotropic effects.
Tavernier et al. (1994) studied this question.
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