June 1, 1994Anesthesia & Analgesia

Role of Intracellular Ca2+ Pools in the Effects of Halothane and Isoflurane on Vascular Smooth Muscle Contraction

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Population

Isolated spiral strips of rat thoracic aorta

Comparison

Halothane or isoflurane vs 0% anesthetic (control) and verapamil

Design

Preclinical

Authors

HTHideaki TsuchidaKanazawa University HNHitoshi NambaAsahikawa City Hospital SSSumihiko SekiSapporo Medical University

Discussion

Member takes

Implication

These animal findings on halothane-isoflurane Ca2+ effects should not change practice; hypothesis-generating for anesthetic impacts on vascular tone.

Structured PICO

Population

Isolated spiral strips of rat thoracic aorta

Intervention

Halothane (1%, 2%, 3%) or isoflurane (1%, 2%, 3%, 4%)

Comparator

0% anesthetic (control) and verapamil

Outcome

Muscle tension and cytosolic Ca2+ levels ([Ca2+]i)surrogate

Halothane and isoflurane differentially affect intracellular Ca2+ pools in vascular smooth muscle, with halothane specifically enhancing release from caffeine-releasable stores.

Cite This Study

Tsuchida et al. (1994) studied this question.

synapsesocial.com/papers/6a9186cf35eca4d44dab66ff https://doi.org/10.1213/00000539-199406000-00006

View Full Paper

Ask AI

Bookmark

Implication

These animal findings on halothane-isoflurane Ca2+ effects should not change practice; hypothesis-generating for anesthetic impacts on vascular tone.

Role of Intracellular Ca2+ Pools in the Effects of Halothane and Isoflurane on Vascular Smooth Muscle Contraction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Role of Intracellular Ca2+ Pools in the Effects of Halothane and Isoflurane on Vascular Smooth Muscle Contraction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider