Why the study?
Do isoflurane, sevoflurane, and halothane have different effects on myofilament Ca2+ sensitivity and SR Ca2+ release in rat ventricular myocytes?
Population
Single rat ventricular myocytes loaded with fura-2
Comparison
Exposure to isoflurane, sevoflurane, and… vs Baseline / low Ca2+ exposure
Design
Preclinical
Follow-up
1 min
Authors
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Anesthetic-specific Ca2+ effects in rat myocytes; hypothesis-generating and should not yet alter clinical anesthetic selection.
Do isoflurane, sevoflurane, and halothane have different effects on myofilament Ca2+ sensitivity and SR Ca2+ release in rat ventricular myocytes?
Different volatile anesthetics exert negative inotropic effects through distinct cellular mechanisms involving myofilament calcium sensitivity and sarcoplasmic reticulum calcium handling.
Davies et al. (2000) studied this question.
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